Wegovy – Zepbound – Ozempic



Obesity is a complex disease characterized by excessive fat accumulation which is caused by genetic, environmental and other factors. In recent years, there has been an increase in the morbidity, disability rate,and mortality due to obesity, making it great threat to people’s health and lives, and increasing public health care expenses. Evidence from previous studies show that weight loss can significantly reduce the risk of obesity-related complications and chronic diseases. Diet control, moderate exercise, behavior modification programs, bariatric surgery and prescription drug treatment are the major interventions used to help people lose weight. Among them, anti-obesity drugs have high compliance rates and cause noticeable short-term effects in reducing obese levels. However, given the safety or effectiveness concerns of anti-obesity drugs, many of the currently used drugs have limited clinical use. Glucagon-like peptide-1 receptor (GLP-1R) agonists are a group of drugs that targets incretin hormone action, and its receptors are widely distributed in nerves, islets, heart, lung, skin, and other organs. Several animal experiments and clinical trials have demonstrated that GLP-1R agonists are more effective in treating or preventing obesity. Therefore, GLP-1R agonists are promising agents for the treatment of obese individuals. This review describes evidence from previous research on the effects of GLP-1R agonists on obesity. We anticipate that this review will generate data that will help biomedical researchers or clinical workers develop obesity treatments based on GLP-1R agonists.


Wegovy (Semaglutide)

  • FDA approval for chronic weight management in adults with obesity or overweight.
  • Mechanism of action as a GLP-1 receptor agonist, which helps regulate appetite and food intake.
  • Efficacy in clinical trials, showcasing average weight loss percentages and duration of use.


Zepbound (Generic Name)

  • Mechanism of action, such as targeting appetite control or metabolic processes.
  • FDA approval for indications in weight management.


Effective Weight Loss:

  • Significant and sustained weight loss when used as part of a comprehensive weight management plan.

Appetite Control

  • These medications help control appetite, reduce food cravings, and promote healthier eating habits.

Safety and Considerations:

  • Common side effects associated with these medications such as nausea, diarrhea, or changes in appetite.
  • It is important to have medical supervision and monitoring while using weight loss medications.

Patient Eligibility:

  • Your insurance decides if it’s covered. You will have to pay out of pocket if your insurance doesn’t cover a GLP-1

How to Use:

Dosage and Administration:

  • Provide general guidance on dosage, frequency of administration, and any special instructions.
  • You are required to follow your healthcare provider’s recommendations and adhere to prescribed regimens.